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Treatment of Acromegaly With the Growth Hormone-Receptor Antagonist Pegvisomant NEJM 342:1171-1177,1210, Trainer,P.J.,et al, 2000 See this aricle in Pubmed Article Abstract Patients with acromegaly are treated with surgery, radiation therapy, and drugs to reduce hypersecretion of growth hormone, but the treatments may be ineffective and have adverse effects. Pegvisomant is a genetically engineered growth hormone-receptor antagonist that bloks the action of growth hormone. On the basis of these preliminary results, treatment of patients who have acromegaly with a growth hormone-receptor antagonist results in a reduction in serum IGF-I concentrations and in clinical improvement.

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